Prairie Doc: Germ theory, antibiotics, and our 21st-century challenge

Germ theory, though it had beginnings smattered in earlier times, really did not take off until discoveries by 19th-century thinkers including Louis Pasteur, Joseph Lister and Robert Koch. This was an exciting time to be a biologist, and in my opinion, these careers are all worthy of blockbuster movies. By the early 1900s, an enormous shift had occurred, and the idea that microorganisms could cause disease was well accepted.

Initially, the discovery of germ theory was most useful in prevention — sanitizing water and food went a long way toward decreasing outbreaks of previously common diseases. But another huge change occurred in 1928 with the discovery of penicillin. Penicillin was a chemical compound secreted by a type of mold which Alexander Fleming found killed bacteria. By the mid-20th century, many other antibiotics were discovered and ultimately used to treat bacterial infections.

Antibiotics are certainly one of the greatest advancements in the history of medicine and have saved countless lives worldwide. However, as our ability to treat them has advanced, bacteria have continued to evolve. Through numerous processes, some types of bacteria have changed in ways to evade once-effective antibiotics. At the same time, the development of new types of antibiotics has slowed to a trickle in the 21st century. Life-threatening bacterial infections for which we have no or limited ability to treat are a real concern for infectious disease experts.

The challenge of our era, I think, is mitigating the danger posed by antibiotic-resistant infections. The most important step we can all take is to reduce the use of antibacterial medication when it is not necessary. Challenges for our hospital teams include looking critically every day to see if and which antibiotics can safely be stopped in hospitalized patients. Preserving the efficacy of this precious resource will be the work of all of us.

Kelly Evans-Hullinger, M.D. is part of The Prairie Doc® team of physicians and currently practices internal medicine in Brookings, South Dakota. Follow The Prairie Doc® at www.prairiedoc.org and on Facebook featuring On Call with the Prairie Doc®, a medical Q&A show providing health information based on science, built on trust, broadcast on SDPB and streaming live on Facebook most Thursdays at 7 p.m. central.